Year: 2017
Type: review
Abstract: Tumors develop in intricate microenvironments required for their sustained growth, invasion, and metastasis. The tumor microenvironment plays a critical role in the malignant or drug resistant nature of tumors, becoming a promising therapeutic target. Microengineered physiological systems capable of mimicking tumor environments are one emerging platform that allows for quantitative and reproducible characterization of tumor responses with pathophysiological relevance. This review highlights the recent advancements of engineered tumor microenvironment systems that enable the unprecedented mechanistic examination of cancer progression and metastasis. We discuss the progress and future perspective of these microengineered biomimetic approaches for anticancer drug prescreening applications.
Source: Bioengineering
Authors: Jungho Ahn, Yoshitaka Sei, Noo Jeon, YongTae Kim
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,258
Funders: American Heart Association, Emory University, Atlanta Clinical and Translational Science Institute, National Research Foundation, National Research Foundation of Korea, National Institutes of Health, College of Computing, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke
Awards: Cell and Tissue Engineering Training Program, G1996733803, Engineering of anti-miRNA Transporting HDL for Treating Endothelial Inflammation in Experimental Atherosclerosis, G4777953589, G5184389995, Targeted delivery of a sonic hedgehog inhibitor for the study of medulloblastoma therapeutics
OpenAlex ID: W2736644389