Late-Onset Hiv Encephalopathy In Children With Long-Standing Virologic Suppression Followed By Slow Spontaneous Recovery Despite no Change In Antiretroviral Therapy
Year: 2017
Type: article
Study design: Case Report
Abstract: We describe 4 Children with HIV Early Antiretroviral Therapy trial participants with late-onset HIV encephalopathy despite long-standing viral suppression in blood and undetectable HIV DNA and RNA polymerase chain reaction in cerebrospinal fluid. Extensive investigations revealed no alternative etiology. Reassuringly, all 4 experienced slow spontaneous recovery despite no change in antiretroviral therapy. Virally suppressed HIV-infected children remain at risk for fluctuating neurologic signs and symptoms.
Institutions: Stellenbosch University, Tygerberg Hospital
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Stellenbosch University Clinical Trial Unit, Cape Town, South Africa, Latent reservoir characterization and correlations with neurocognitive functionin, CIPRA-SA: Safeguard the household: comprehensive AIDS research: Extension, Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMC, San Diego Center for AIDS Research (SD CFAR), Stellenbosch University Clinical Trials Unit
OpenAlex ID: W2737788189