Work

Response to Comment on Niewczas et al. Circulating Modified Metabolites and a Risk of ESRD in Patients With Type 1 Diabetes and Chronic Kidney Disease. Diabetes Care 2017;40:383–390

Year: 2017

Type: letter

Abstract: We appreciate the invitation to respond to comments by Luo et al. (1) on our article (2). The clinical ascertainment of exposures and the outcome is crucial for epidemiological studies and we appreciate the given attention. The goal of our study was to evaluate metabolomic determinants predicting development of end-stage renal disease (ESRD) 10 years in advance. Apparently, we were not explicit in explaining that our study design was prospective and not cross-sectional. Luo et al. (1) mentioned limitations regarding the use of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to estimate glomerular filtration rate in the elderly and in subjects with certain CKD stages or to define ESRD. These might be valid diagnostic concerns relevant in the cross-sectional setting, but they are not applicable to our prospective study. We chose development of ESRD within 8–12 years, an …

Source: Diabetes Care

DOI: 10.2337/dci17-0009

Authors: Monika A. Niewczas, Andrzej S. Krolewski

Institutions: Joslin Diabetes Center, Harvard University

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Juvenile Diabetes Research Foundation United States of America, National Institute of Diabetes and Digestive and Kidney Diseases