Natural Products and Their Mimics as Targets of Opportunity for Discovery
Year: 2017
Type: article
Abstract: Diverse structural types of natural products and their mimics have served as targets of opportunity in our laboratory to inspire the discovery and development of new methods and strategies to assemble polyfunctional and polycyclic molecular architectures. Furthermore, our efforts toward identifying novel compounds having useful biological properties led to the creation of new targets, many of which posed synthetic challenges that required the invention of new methodology. In this Perspective, selected examples of how we have exploited a diverse range of natural products and their mimics to create, explore, and solve a variety of problems in chemistry and biology will be discussed. The journey was not without its twists and turns, but the unexpected often led to new revelations and insights. Indeed, in our recent excursion into applications of synthetic organic chemistry to neuroscience, avoiding the more-traveled paths was richly rewarding.
Source: The Journal of Organic Chemistry
Author: Stephen F. Martin
Institution: The University of Texas at Austin
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: Welch Foundation, Boehringer Ingelheim, Abbott Laboratories, Bristol-Myers Squibb, Pfizer, Merck, Sanofi, DuPont, Procter and Gamble, Chevron, Alexander von Humboldt-Stiftung, BrightFocus Foundation, F. Hoffmann-La Roche, Takeda Pharmaceutical Company, Elan, Daiichi Sankyo Company, National Institute of General Medical Sciences, Division of Chemistry
OpenAlex ID: W2738162949