Work

Comment on “The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport”

Year: 2017

Type: article

Abstract: (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.

Source: Science

DOI: 10.1126/science.aan2396

Authors: Andrey G. Baranovskiy, Nigar D. Babayeva, Yinbo Zhang, Luis Blanco, Youri I. Pavlov, Tahir H. Tahirov