Year: 2017
Type: dissertation
Abstract: The aim of this thesis was to develop the use of therapeutic and substance abuse biomarkers relevant to the immediate postpartum period, to reduce the risk of adverse outcomes in mothers and their infants. A systematic review was conducted to identify the role of opioid pharmacogenetics in analgesic response among postpartum patients, and in adverse events in these patients and their breastfed infants. Following a thorough search of the literature, studies were screened for their eligibility, data was extracted, and study quality was evaluated. Collectively, the 17 studies included in the review revealed that CYP2D6, OPRM1 A118G, UGT2B7 C802T and ABCB1 G2677AT may contribute to postpartum analgesia or adverse events. A nested cohort study was performed to explore the role of codeine pharmacogenetics in a population of 98 post-cesarean women. Participants were genotyped and instructed to report their pain using the visual analog scale 1 h following each dose of codeine. The OPRM1 A118G and UGT2B7 C802T variants were found to predict codeine consumption in the cohort overall (P
Source: TSpace (University of Toronto)
Author: Marta Baber
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2738436034