Work

A Strong Hybrid Fatty Acid Inducible Transcriptional Sensor Built From Yarrowia lipolytica Upstream Activating and Regulatory Sequences

Year: 2017

Type: article

Source: Biotechnology Journal

DOI: 10.1002/biot.201700248

Authors: Murtaza Shabbir Hussain, Ian Wheeldon, Mark A. Blenner

Institutions: Clemson University, University of California, Riverside

Language: English

Topic: Microbial Metabolic Engineering and Bioproduction

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: closed

Funders: National Aeronautics and Space Administration, Clemson University, Division of Chemical, Bioengineering, Environmental, and Transport Systems

Awards: G2346469173, G8793940259, SYNTHETIC BIOLOGY FOR RECYCLING HUMAN WASTE INTO NUTRACEUTICALS AND MATERIALS: CLOSING THE LOOP FOR LONG-TERM SPACE TRAVEL IT IS IMPRACTICAL FOR ASTRONAUTS TO TRAVEL WITH ALL NECESSARY SUPPLIES IN FUTURE LONG-TERM SPACE EXPLORATION MISSIONS. THEREFORE IT IS IMPERATIVE THAT TECHNOLOGIES ENABLING THE PRODUCTION OF FOOD NUTRACEUTICALS MEDICINE AND MATERIALS FROM EXTRATERRESTRIAL RESOURCES ARE DEVELOPED. THESE RESOURCES FOUND IN SPACE INCLUDE MINERALS AND FEEDSTOCKS FOUND ON DISTANT BODIES WASTE GENERATED BY HUMANS AND SPACE SHUTTLE OPERATION AND SOLAR ENERGY. TOGETHER WITH SYNTHETIC BIOLOGY-DRIVEN TECHNOLOGY FOR ENGINEERING MICROORGANISMS THAT CAN RELIABLY EFFICIENTLY AND FLEXIBLY UTILIZE SUCH "IN SITU RESOURCES" ASTRONAUTS WILL BE ABLE TO GENERATE THE FOOD NUTRACEUTICALS MEDICINE AND MATERIALS THEY NEED TO CARRY OUT THEIR MISSION. DUE TO POTENTIAL UNCERTAINTY IN RESOURCE AVAILABILITY THIS PROPOSAL FOCUSES ON ENGINEERING YEAST TO CONVERT RESPIRATION CO2 ALGAE BIOMASS AND HUMAN URINE INTO NUTRITIONAL OMEGA-3 FATS AND 3D PRINTABLE PLASTICS.

OpenAlex ID: W2738705446

FWCI: 1.959

Cites: 60

Cited by: 46

Related to: 10