The Association of Inflammatory Markers With Nonalcoholic Fatty Liver Disease Differs by Human Immunodeficiency Virus Serostatus
Year: 2017
Type: article
Abstract: Background We aimed to determine the relationship of circulating adipokines and inflammatory biomarkers with fatty liver among men in the Multicenter AIDS Cohort Study. Methods Noncontrast computed tomography was used to assess fatty liver and measure abdominal visceral adipose tissue (VAT) area in 526 participants without history of cardiovascular disease, heavy alcohol use, or viral hepatitis infection. Multivariable logistic regression was used to assess associations of circulating biomarker levels with fatty liver. Results Three hundred twenty-nine human immunodeficiency virus (HIV)-infected men had higher levels of several inflammatory biomarkers compared with 197 HIV-uninfected men. Among HIV-uninfected men, increased adiponectin was associated with lower odds of fatty liver (odds ratio [OR] = 0.51 per doubling, P = .02), whereas higher odds of fatty liver was observed with increased levels of the proinflammatory markers intercellular adhesion molecule (ICAM)-1 (OR = 5.30, P = .004), C-reactive protein (OR = 1.66, P = .002), interleukin (IL)-6 (OR = 1.67, P = .03), and tumor necrosis factor α receptor 2 (OR = 6.55, P = .003). Among HIV-infected men, ICAM-1 was the only proinflammatory marker associated with greater odds of fatty liver (OR = 2.67, P = .02), whereas higher adiponectin (OR = 0.57, P = .003), and osteoprotegerin levels (OR = 0.48, P = .03) were associated with lower odds. These associations were all independent of VAT. Conclusions Fatty liver is associated with a heightened inflammatory state independent of visceral adiposity in HIV-uninfected men but not in HIV-infected men. However, a heightened anti-inflammatory state may protect against fatty liver regardless of HIV serostatus.
Source: Open Forum Infectious Diseases
DOI: 10.1093/ofid/ofx153
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,053
Funders: Bristol-Myers Squibb, Gilead Sciences, Northwestern University, American College of Gastroenterology, Johns Hopkins University, University of Pittsburgh, National Institutes of Health, University of California, Los Angeles, University of California, San Francisco, Johns Hopkins Bloomberg School of Public Health, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: Center/Coordination, Analysis and Management/MACS, UCLA Clinical and Translational Science Institute, Natural History of AIDS in Homosexual Men, University of Pittsburgh Multicenter AIDS Cohort Study (MACS), Institute for Clinical and Translational Research, Multicenter AIDS Cohort Study, Subclinical Vascular Disease and Metabolic Abnormalities in MACS, Multicenter AIDS Cohort Study - Part B (Baltimore Center), UCSF Liver Center, UCLA Clinical and Translational Science Institute
OpenAlex ID: W2738751507