Work

Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices

Year: 2017

Type: article

Abstract: ) of LPNPs while maintaining the physicochemical properties. Finally, we present robust and reliable manufacturing of NPs by integrating the parallelized SMR platform with our custom high-precision feedback control system that addresses unpredictable disturbances during the production. Our approach may contribute to efficient development and optimization of a wide range of multicomponent NPs for medical imaging and drug delivery, ultimately facilitating good manufacturing practice (GMP) production and accelerating the clinical translation.

Source: Lab on a Chip

DOI: 10.1039/c7lc00668c

Authors: Michael J. Toth, Taeyoung Kim, YongTae Kim

Institutions: Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green