Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy.
Year: 2016
Type: article
Abstract: was neuroprotective shown both by the enhanced recovery of EEG and by the significant preservation of neurons in the cerebral cortex, hippocampus, basal ganglia, and the thalamus. H2 appeared to reduce oxidative stress shown by attenuation of 8-hydroxy-2'-deoxyguanosine immunostaining. In summary, this new PA piglet model is able to induce moderate/severe HIE, and the efficacy of hydrogen post-treatment to preserve neuronal activity/function in this PA/HIE model suggests the feasibility of this safe and inexpensive approach in the treatment of asphyxiated babies.
Source: PubMed
Authors: J Nemeth, V Toth-Szuki, V Varga, V Kovacs, G Remzso, F Domoki
Institution: University of Szeged
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
Funder: Magyar Tudományos Akadémia
OpenAlex ID: W2738959165