Work

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Year: 2017

Type: review

Abstract: During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high‐pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed. We provide a brief description of the history, principle, and various preparation methods involved in the SCF technology. Next, we aim to give a brief overview, which provides an emphasis and discussion of recent reports using supercritical carbon dioxide (SC‐CO2) for fabrication of polymeric carriers, for applications in areas related to drug delivery, tissue engineering, bio‐imaging, and other biomedical applications. We finally summarize with perspectives.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201700433

Authors: Ranjith Kumar Kankala, Yu Shrike Zhang, Shi‐Bin Wang, Chia‐Hung Lee, Ai‐Zheng Chen

Institutions: Huaqiao University, Brigham and Women's Hospital, Harvard University, National Dong Hwa University

Language: English

Topic: Phase Equilibria and Thermodynamics

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,880