Year: 2013
Type: dissertation
Abstract: This thesis investigated the role of O\\(_2\\)-dependent substances in mediating the vasodilatation seen following exercise (post-exercise hyperaemia) and in fatigue development. Additionally we compared young and old subjects to investigate the effects of ageing in both of these phenomena. \nBreathing supplementary 40% O\\(_2\\) during handgrip exercise at 50% of maximum voluntary contraction had no effect of the magnitude of post-exercise hyperaemia compared to air breathing control. Furthermore, aspirin administration did not alter magnitude of post-exercise hyperaemia or the levels of prostaglandin E metabolites assayed from the forearm venous efflux. Similarly the magnitude of post-exercise hyperaemia was not affected by aminophylline administration. Collectively these suggest that prostaglandins and adenosine are not obligatory mediators of post-exercise hyperaemia. \nSupplementary O\\(_2\\) breathed during recovery had no effect on fatigue in a second bout of exercise or any of the substances proposed to mediate fatigue, in young subjects. We demonstrated that older subjects showed no changes in the magnitude of post-exercise hyperaemia, but they were more fatigue resistant. There was no O\\(_2\\)-dependence of either post-exercise hyperaemia or fatigue in older subjects. \nIn conclusion, we have found no evidence of O\\(_2\\)-dependent mediators in either post-exercise hyperaemia or fatigue. \n
Author: Christopher S. Davies
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: British Heart Foundation
OpenAlex ID: W27395955