Work

Clinical Islet Xenotransplantation: A Step Forward

Year: 2016

Type: article

Abstract: With the encouraging results of pancreatic islet allotransplantation, increasing attention is being directed towards pig islet xenotransplantation, which would resolve the problem of islet supply (Markmann et al., 2016; Ekser et al., 2012). Free (nonencapsulated) pig islets (either wild-type or genetically-engineered) have maintained normoglycemia in immunosuppressed diabetic nonhuman primates for >1year (Park et al., 2015). Immunoisolated (encapsulated) pig islets have maintained normoglycemia in non-immunosuppressed diabetic nonhuman primates for up to 6months (Dufrane et al., 2006).

Source: EBioMedicine

DOI: 10.1016/j.ebiom.2016.09.023

Authors: Burcin Ekser, Rita Bottino, David K.C. Cooper

Institutions: Indiana University Indianapolis, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis, Allegheny-Singer Research Institute, University of Pittsburgh

Language: English

Topic: Xenotransplantation and immune response

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,780