Work

Considerations for Infectious Disease Research Studies Using Animals.

Year: 2017

Type: article

Abstract: Animal models are vital in understanding the transmission and pathogenesis of infectious organisms and the host immune response to infection. In addition, animal models are essential in vaccine and therapeutic drug development and testing. Prior to selecting an animal model to use when studying an infectious agent, the scientific team must determine that sufficient in vitro and ex vivo data are available to justify performing research in an animal model, that ethical considerations are addressed, and that the data generated from animal work will add useful information to the body of scientific knowledge. Once it is established that an animal should be used, the questions become 'Which animal model is most suitable?' and 'Which experimental design issues should be considered?' The answers to these questions take into account numerous factors, including scientific, practical, welfare, and regulatory considerations, which are the focus of this article.

Source: Europe PMC (PubMed Central)

Authors: Lesley A Colby, Lauriane E Quenee, Lois A Zitzow

Institutions: University of Washington, California Institute of Technology, University of Georgia

Language: English

Topic: Animal testing and alternatives

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2739987255

FWCI: 6.253

Cites: 60

Cited by: 51

Related to: 10