Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine
Year: 2017
Type: article
Abstract: Foiling bad bugs' sneaky tricks Intestinal pathogens can invade host cells and disrupt critical cellular functions, including secretion. Secretion is necessary for the delivery of antimicrobial proteins that kill pathogenic bacteria. Bel et al. show that when intestinal epithelial cells sense an invading bacterial pathogen, they “reroute” the antimicrobial protein lysozyme through an alternative autophagy-based secretion pathway (see the Perspective by Kaser and Blumberg). This ensures lysozyme delivery to the gut lumen, which protects against further bacterial invasion. Secretory autophagy was triggered by endoplasmic reticulum stress and required signals from type 3 innate lymphoid cells. Thus, the innate immune response to gut pathogens co-opts autophagy in intestinal immune defense. Science , this issue p. 1047 ; see also p. 976
Source: Science
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
Awards: G1277860013, G1636559349, G1658098344, G2017564300, G2119574190, G27061350, G3982605246, Lactate metabolism during Salmonella infection, G4687809162, G4837399037, Autophagy Modulators as Novel Broad-Spectrum Anti-Infective Agents, Analysis of autophagy risk genes in inflammation and tissue homeostasis, G8046271324, G8530376202, Integrative Immunology Training Grant, Central metabolism of Salmonella in the inflamed gut, Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital, Microbial Regulation of Retinol Transport and its Role in Intestinal Immunity
OpenAlex ID: W2740220090