Rapid decline in lung function in healthy adults predicts incident excess urinary albumin excretion later in life

Year: 2017

Type: article

Abstract: INTRODUCTION: Chronic lung disease, often characterised by rapid decline in lung function, is associated with vascular endothelial dysfunction (characterised by moderate to severe excess urinary albumin excretion (eUAE) but their longitudinal relationship is inadequately studied. In a bidirectional longitudinal examination of healthy adults, we analysed the following two hypotheses: (1) rapid decline (ie, highest tertile of lung function decline) predicts eUAE and (2) eUAE predicts rapid decline. METHODS: We performed a secondary data analysis from 3052 eligible participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study. For analysis 1, the predictor was rapid decline in lung function between the peak value (attained at or before CARDIA visit year 10 or Y10 at a mean age of 35 years) and Y20; and the outcome was incident eUAE at Y20 and/or Y25. For analysis 2, the predictor was eUAE at Y10 and the outcome was rapid decline between Y10 and Y20. RESULTS: or FVC between peak and Y20 predicted incident eUAE at Y20 and/or Y25 (OR 1.51 and 1.44, respectively; p≤0.05 for both analyses). In analysis 2, eUAE at Y10 did not predict subsequent rapid decline. CONCLUSIONS: Healthy adults with rapid decline in lung function are at risk for developing vascular endothelial dysfunction, as assessed by incident eUAE, later in life.

Source: BMJ Open Respiratory Research

DOI: 10.1136/bmjresp-2017-000194

Authors: Sapna Bhatia, Clifford Qualls, Thomas A Crowell, Alexander Arynchyn, Bharat Thyagarajan, Lewis J Smith, Ravi Kalhan, David R Jacobs, Holly Kramer, Daniel Duprez, Bartolome Celli, Akshay Sood

Institutions: University of New Mexico, University of Alabama at Birmingham, University of Minnesota, Northwestern University, Loyola University Medical Center, Loyola University Chicago, Loyola Medicine, Brigham and Women's Hospital, University of New Mexico Health Sciences Center

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,085

Funders: Northwestern University, University of Minnesota, Johns Hopkins University, University of Alabama at Birmingham, University of Alabama, Kaiser Foundation Research Institute, School of Medicine, Johns Hopkins University, National Institute on Aging, National Heart, Lung, and Blood Institute

OpenAlex ID: W2740306301