Year: 2016
Type: dissertation
Study design: Observational Study
Abstract: PSP is a neurodegenerative movement disorder that is characterized by the pathological accumulation of tau aggregates in the brain. PSP differs neuropathologically from other movement disorders such as PD and MSA, which are classified as synucleinopathies. PSP patients would benefit from a clinically approved tau imaging agent for diagnostic and prognostic purposes. Previous testing of the tau radiotracer [18F]AV-1451 in AD, another tauopathy, suggested that it was capable of distinguishing AD from MCI and healthy controls. The aim of this investigation was to test whether [18F]AV-1451 was able to distinguish PSP patients from PD patients and healthy controls. There were no significant increases in [18F]AV-1451 retention in PSP patients compared to the other two subject groups. These findings may indicate that [18F]AV-1451 is not an effective radiotracer for imaging tau in PSP, or perhaps the method of measuring [18F]AV-1451 retention used in this study was not appropriate.
Source: TSpace (University of Toronto)
Author: Sarah Coakeley
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2740383003