Work

CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment

Year: 2017

Type: article

Abstract: To the editor: Germ line–activating mutations of protein tyrosine phosphatase PTPN11 (Shp2), a positive regulator of the Ras signaling pathway,[1][1] account for more than 50% of patients with Noonan syndrome.[2][2] These patients have an increased risk of developing leukemias,[3][3] especially

Source: Blood

DOI: 10.1182/blood-2017-06-791103

Authors: Lei Dong, Hong Zheng, Cheng-Kui Qu

Institutions: Emory University, Children's Healthcare of Atlanta

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases