Work

Analytic Considerations for Repeated Measures of eGFR in Cohort Studies of CKD

Year: 2017

Type: review

Abstract: Repeated measures of various biomarkers provide opportunities for us to enhance understanding of many important clinical aspects of CKD, including patterns of disease progression, rates of kidney function decline under different risk factors, and the degree of heterogeneity in disease manifestations across patients. However, because of unique features, such as correlations across visits and time dependency, these data must be appropriately handled using longitudinal data analysis methods. We provide a general overview of the characteristics of data collected in cohort studies and compare appropriate statistical methods for the analysis of longitudinal exposures and outcomes. We use examples from the Chronic Renal Insufficiency Cohort Study to illustrate these methods. More specifically, we model longitudinal kidney outcomes over annual clinical visits and assess the association with both baseline and longitudinal risk factors.

Source: Clinical Journal of the American Society of Nephrology

DOI: 10.2215/cjn.11311116

Authors: Haochang Shou, Jesse Y. Hsu, Dawei Xie, Wei Yang, Jason Roy, Amanda H. Anderson, J. Richard Landis, Harold I. Feldman, Afshin Parsa, Christopher Jepson, on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators

Institutions: University of Pennsylvania, University of Maryland, Baltimore, Baltimore VA Medical Center

Language: English

Topic: Statistical Methods and Bayesian Inference

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences

Awards: Clinical and Translational Science Institute, Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study, General Clinical Research Center, Center for Clinical and Translational Science, Michigan Institute for Clinical and Health Research (MCHR), Michigan Institute for Clinical and Health Research (MICHR), Institute for Clinical and Translational Research, Institutional Clinical and Translational Science Award, Clinical and Translational Science Award, Clinical and Translational Science Collaborative of Cleveland, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases, Prospective renal insufficiency cohort evaluation: PRICE, Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center, Continuation of the University of Illinois Chicago CRIC Clinical Center, Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center, Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study, Chronic Renal Insufficiency Cohort Limited competition continuation, Chronic Renal Insufficiency Cohort (CRIC) Study

OpenAlex ID: W2741011360

FWCI: 0.704

Cites: 73

Cited by: 52

Related to: 10