Phenol Concentrations During Childhood and Subsequent Measures of Adiposity Among Young Girls
Year: 2017
Type: article
Study design: Observational Study
Abstract: Phenolic compounds represent a class of environmental chemicals with potentially endocrine-disrupting capabilities. We investigated longitudinal associations between childhood exposure to phenols, from both manmade and natural sources, and subsequent measures of adiposity among girls enrolled in the Breast Cancer and the Environment Research Program between 2004 and 2007. Baseline (ages 6-8 years) urinary concentrations were obtained for creatinine and phenol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, the sum of parabens (methyl, ethyl, and propyl parabens), 2,5-dichlorophenol, and triclosan. Body mass index (weight (kg)/height (m)2), waist circumference, and percent body fat were measured at annual or semiannual examinations through 2015 (n = 1,017). Linear mixed-effects regression was used to estimate how baseline concentrations of phenols (tertile groups) were related to changes in girls' adiposity measurements from ages 7 through 15 years. Enterolactone was inversely associated with body mass index, waist circumference, and percent body fat, while 2,5-dichlorophenol was positively associated with these measurements. A nonmonotonic association was observed for triclosan and girls' adiposity; however, it was due to effect modification by baseline overweight status. Triclosan was positively associated with adiposity only among overweight girls. These results suggest that exposure to specific phenols during childhood may influence adiposity through adolescence.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwx136
Institution: New York University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: bronze
Funders: Avon Foundation for Women, Environmental Protection Agency, National Institutes of Health, National Cancer Institute, National Institute of Environmental Health Sciences, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Inner City Toxicants, Child Growth and Development, Breast Cancer and the Environment Research Center, Breast Cancer and the Environment Research Program Coordinating Center, G2294136274, Center for Environment and Mammary Gland Development, Mount Sinai Institutes for Clinical and Translational Sciences, Puberty & Cancer Initiation: Environment Diet & Obesity, Center for Environmental Genetics, G424471100, Effects of BPA and Phthalates on Adiposity and Metabolic Risk Factors in Women, The CYGNET Study: Enviromental and Genetic Determinants of Maturation of Girls, Continued studies of environment impact on puberty, Bay Area Breast Cancer & the Environment Research Center, G7543494365, Environmental and Genetic Determinants of Puberty, G8873203375, Research Training Program in Pediatric Exposomics, Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)
OpenAlex ID: W2741362837