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Alpha power oscillation in the frontal cortex under Bromazepam and Modafinil effects

Year: 2015
Type: article
Abstract: OBJECTIVE: Our aim was to investigate and compare the neuromodulatory effects of bromazepam (6 mg) and modafinil (200 mg) during a sensorimotor task analyzing the changes produced in the absolute alpha power. METHOD: The sample was composed of 15 healthy individuals exposed to three experimental conditions: placebo, modafinil and bromazepam. EEG data were recorded before, during and after the execution of the task. A three-way ANOVA was applied, in order to compare the absolute alpha power among the factors: Group (control, bromazepam and modafinil) Condition (Pre and Post-drug ingestion) and Moment (pre and post-stimulus). RESULTS: Interaction was found between the group and condition factors for Fp1, F4 and F3. We observed a main effect of moment and condition for the Fp2, F8 and Fz electrodes. CONCLUSION: We concluded that drugs may interfere in sensorimotor processes, such as in the performance of tasks carried out in an unpredictable scenario.
DOI: 10.1590/0004-282x20150140
Authors: Danielle Aprigio, Washington Adolfo, Juliana Bittencourt, Mariana Gongora, Silmar Teixeira, Luis Fernando Basile, Henning Budde, Mauricio Cagy, Pedro Ribeiro, Bruna Velasques
Institutions: Universidade Federal do Rio de Janeiro, Universidade Veiga de Almeida, Universidade Federal do Piauí, Universidade Metodista de São Paulo, Universidade de São Paulo, Reykjavík University, MSH Medical School Hamburg – University of Applied Sciences and Medical University
Language: English
Open Access status: gold
Estimated APC paid: $200
OpenAlex ID: W2261155725
FWCI: 0.164
Cites: 29
Cited by: 3
Related to: 10