Nonalcoholic Steatohepatitis is Associated with Cardiac Remodeling and Dysfunction
Year: 2017
Type: article
Study design: Observational Study
Abstract: Objective Preliminary data suggest that nonalcoholic fatty liver disease is associated with early heart failure (HF). However, whether nonalcoholic steatohepatitis (NASH) is directly associated with echocardiographic changes in cardiac structure or function remains unknown. Methods A retrospective cohort was identified of individuals (N = 65) without known heart disease, undergoing elective bariatric surgery with perioperative liver biopsy, and available recent transthoracic echocardiography (TTE). TTE measures were evaluated by NASH status using correlation coefficients, ANOVA, and linear regression, accounting for cardiometabolic factors. Results Median age was 47 years; 22% (n = 14) had NASH. NASH patients had increased median left atrial (LA) volume (28.6 mL/m2 vs. 24.8 mL/m2; P < 0.0001) and left ventricular (LV) mass (82.6 g/m2 vs. 78.6 g/m2; P < 0.0001), indexed for height. NASH was inversely correlated with indices of diastolic function, including septal E′ (r = −0.90 [95% CI: −1.21 to −0.42]; P = 0.020) and E:A (r = −0.31 [95% CI: −0.51 to −0.09]; P = 0.037). In adjusted analyses, NASH remained associated with increased LV mass index (ß1 = 7.16 [SE: 4.95]; P = 0.001) and LA volume index (ß1 = 0.19 [SE: 0.08]; P = 0.001) and reduced lateral and septal E′ (ß1 = −0.91, P = 0.015; ß1 = −0.89, P = 0.047, respectively). Conclusions In this bariatric cohort, NASH was associated with changes in myocardial structure and in load‐dependent indices of LV diastolic function, suggestive of subclinical HF.
Source: Obesity
DOI: 10.1002/oby.21879
Institutions: Harvard University, Massachusetts General Hospital
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2742007594