Work

The innate immune response in human tuberculosis

Year: 2015

Type: review

Abstract: Mycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini-review, we discuss these host-pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome-wide association studies).

Source: Cellular Microbiology

DOI: 10.1111/cmi.12480

Authors: Thomas R. Lerner, Sophie Borel, Maximiliano G. Gutierrez

Institution: National Institute for Medical Research

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,350