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Determinantes biopsicosociales de depresión en pacientes atendidos en Centros de Atención Primaria de Concepción, Chile

Year: 2016

Type: article

Abstract: Introduction: Risk factors associated to depression have been extensively studied, though there is a lack of prospective studies on factors that predict the incidence of depression in healthy people.There is not a predictive equation that incorporates genetic factors is not available.Method: A cohort study, prospective, with baseline assessments at 12 months was carried out on a random sample of attendees in primary care centers form the Concepción Province, Chile (n = 1,596).Eight psychosocial factors were measured and the genotyping of the uMAO and 5-HTTLPR in SLC6A4 as genetic factors polymorphisms was also carried out.The outcome variable was the presence/absence of depression at 12 months follow-up.A predictive model for depression was obtained by means of analyses of binary logistic regression.Results: Genetic variables have no statistically significant relation with the variable depression at 12 months follow up.Variables such as gender, educational level, satisfaction with living conditions, personal background of depression, self perception of both physical and mental health and satisfaction with relationship are related to the onset of depression in the follow up.Conclusions: Outcomes will allow identifying vulnerable people among the primary care attendees, who could participate in prevention programs.The study of further genes will be necessary in order to improve the predictive capacity of the model.

Source: Revista chilena de neuro-psiquiatría

DOI: 10.4067/s0717-92272016000200004