Work

Neutrophil extracellular trap (NET) levels in human plasma are associated with active TB

Year: 2017

Type: article

Study design: Observational Study

Abstract: Neutrophils are increasingly associated with tuberculosis (TB) disease. Neutrophil extracellular traps (NETs), which are released by neutrophils as a host antimicrobial defense mechanism, are also associated with tissue damage. However, a link between NET levels and TB disease has not been studied. Here we investigate plasma NETs levels in patients with active pulmonary tuberculosis using an ELISA assay that is suitable for high-throughput processing. We show that plasma NETs levels at baseline correlated with disease severity and decreased with antibiotic therapy. Our study demonstrates the biologic plausibility of measuring NETs in plasma samples from patients with TB.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0182587

Authors: Marcos C. Schechter, Kristina Buac, Toidi Adekambi, Stephanie Cagle, Justine Celli, Susan M. Ray, Christina C. Mehta, Balázs Rada, Jyothi Rengarajan

Institutions: Emory University, University of Georgia

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382

Funders: Emory University, University of Georgia, Center for AIDS Research, University of Washington, Center for AIDS Research, Emory University, National Institute of Allergy and Infectious Diseases, Fogarty International Center

Awards: Role of Mycobacterium tuberculosis protease in pathogenesis and host response, Perturbation of antigen-specific T cell responses in latent TB/SIV co-infection, G2675028044, G3094086834, G6113675784, Center for AIDS Research at Emory University

OpenAlex ID: W2742924949

FWCI: 1.979

Cites: 21

Cited by: 50

Related to: 10