Year: 2017
Type: article
Study design: Observational Study
Abstract: // Anurag K. Singh 1 , Christina Mimikos 2 , Adrienne Groman 3 , Shiva Dibaj 3 , Alexis J. Platek 1 , David M. Cohan 2 , Wesley L. Hicks Jr 2 , Vishal Gupta 2 , Hassan Arshad 2 , Moni A. Kuriakose 2 , Graham W. Warren 4, 5 and Mary E. Platek 2, 6 1 Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA 2 Department of Head and Neck/Plastic and Reconstructive Surgery, Roswell Park Cancer Institute, Buffalo, NY, USA 3 Department of Biostatistics, Roswell Park Cancer Institute, Roswell Park Cancer Institute, Buffalo, NY, USA 4 Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA 5 Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, SC, USA 6 Department of Health, Nutrition and Dietetics, Buffalo State College (SUNY), Buffalo, NY, USA Correspondence to: Anurag K. Singh, email: [email protected] Keywords: tonsillar fossa, TORS, SCCHN, HPV, IMRT Received: January 13, 2017 Accepted: July 31, 2017 Published: August 10, 2017 ABSTRACT Objective: The study evaluated the addition of surgery (S) to radiation (RT) on survival of squamous cell carcinomas (SCC) of tonsillar-fossa (TF) in a modern cohort with similar epidemiology and treatment as current patients. Study Design: Retrospective analysis utilizing Surveillance, Epidemiology, and End Results (SEER) Program data. Results: For all stages combined TF patients who received S+RT had superior OS ( p < 0.01) and DSS ( p < 0.01). For each stage OS and DSS was superior for S+RT ( p < 0.05). In multivariate analysis, HRs for OS were statistically significantly higher for TF patients (stage 2, 3, and 4) receiving RT alone ( p < 0.001). Materials and Methods: TF SCC patients treated with either S+RT or RT alone between 2004 and 2011 were examined ( n = 6,476). Primary outcome measures included overall survival (OS) and disease specific survival (DSS). Cox proportional hazard ratios (HR) were estimated for patients treated with S+RT compared to RT alone. Conclusions: OS and DSS were superior for all stages combined and for stages 2, 3, and 4 in TF patients who received S+RT compared to RT alone.
Source: Oncotarget
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2743398919