Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study
Year: 2017
Type: preprint
Study design: Observational Study
Abstract: ABSTRACT Schizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical, and behavioral scales from 1,115 cases and controls. Significant associations were observed with two cerebrospinal fluid volumes: the temporal horn of left lateral ventricle was associated with NRXN1 , and the volume of the cavum septum pellucidum was associated with LRP1B and RORA . Both volumes were associated with illness. Suggestive associations were observed with local gyrification indices, fractional anisotropy and age at onset. The deep phenotyping approach allowed unexpected genetic sharing to be found between phenotypes, including temporal horn of left lateral ventricle and age at onset.
DOI: 10.1101/175489
Authors: Ney Alliey-Rodriguez, Tamar A Grey, Rebecca Shafee, Jaya Padmanabhan, Neeraj Tandon, Madeline Klinger, Jonathan Spring, Lucas Coppes, Katherine Reis, Matcheri S Keshavan, Diane Gage, Steven McCarroll, Jeffrey R Bishop, Scot Hill, James L Reilly, Rebekka Lencer, Brett Clementz, Peter Buckley, Shashwath Meda, Balaji Narayanan, David C Glahn, Godfrey Pearlson, Elena I Ivleva, Carol Tamminga, John A Sweeney, David Curtis, Sarah Keedy, Judith A Badner, Chunyu Liu, Elliot S Gershon
Institutions: University of Chicago, Massachusetts Institute of Technology, Broad Institute, Harvard University, University of Minnesota, Rosalind Franklin University of Medicine and Science, Northwestern University, University of Münster, University of Georgia, Virginia Commonwealth University, Yale University, The University of Texas Southwestern Medical Center, Queen Mary University of London, University College London, Rush University Medical Center, University of Illinois Chicago
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2743453544