Neural EGF-like protein 1 (NELL-1): Signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine
Year: 2017
Type: article
Abstract: Bone tissue regeneration holds the potential to solve both osteoporosis and large skeletal defects, two problems associated with significant morbidity. The differentiation of mesenchymal stem cells into the osteogenic lineage requires a specific microenvironment and certain osteogenic growth factors. Neural EGF Like-Like molecule 1 (NELL-1) is a secreted glycoprotein that has proven, both in vitro and in vivo , to be a potent osteo-inductive factor. Furthermore, it has been shown to repress adipogenic differentiation and inflammation. NELL-1 can work synergistically with other osteogenic factors such as Bone Morphogenic Protein (BMP) −2 and −9, and has shown promise for use in tissue engineering and as a systemically administered drug for the treatment of osteoporosis. Here we provide a comprehensive up-to-date review on the molecular signaling cascade of NELL-1 in mesenchymal stem cells and potential applications in bone regenerative engineering.
Source: Genes & Diseases
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,500
Funders: U.S. Department of Defense, Scoliosis Research Society, University of Chicago, Ministry of Science and Technology of the People's Republic of China, Ministerio de Ciencia y Tecnología, National Institutes of Health, National Key Research and Development Program of China, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Dental and Craniofacial Research, National Center for Advancing Translational Sciences, National Center for Complementary and Integrative Health
Awards: G1557130165, Summer Program to Increase Diversity in Biomedical Research & Physician Workforce - Renewal 01, G1945244547, G1952862194, G403012309, G406168540, Short Term Training: Health Professional Students, G7049188419, G762061753, G8628954539, G898378059, G9000086257, G9000177286, Cancer Center Support Grant
OpenAlex ID: W2743517102