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Efficacy of Botox versus Placebo for Treatment of Patients with Major Depression.

Year: 2017

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: BACKGROUND: Treatment of major depression is crucial to decrease the burden of disease. Hence, in this study, the efficacy of Botox was compared with placebo for treatment of patients with major depression. METHODS: In this randomized clinical trial, 28 consecutive patients with major depression were enrolled. The patients were randomly assigned to receive either Botox or placebo and the scores of Beck Depression Inventory were determined and compared at baseline and after two and six weeks in the groups and between the groups. In addition, the drug adverse effects were compared between groups. This study had been registered in TCTR with TCTR20170409001 code. RESULTS: >0.05). None of the patients experienced side effects. CONCLUSION: Finally, Botox is effective for treatment of patients with major depression and it has a high safety.

Source: PubMed Central

Authors: Abbas Zamanian, Atefeh Ghanbari Jolfaei, Golnaz Mehran, Zahra Azizian

Institutions: Iran University of Medical Sciences, Rasool Akram Hospital, Tehran University of Medical Sciences

Language: English

Topic: Treatment of Major Depression

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2743778946

FWCI: 1.409

Cites: 17

Cited by: 41

Related to: 10