Work

Noninvasive measurement of tissue blood oxygenation with Cerenkov imaging during therapeutic radiation delivery

Year: 2017

Type: article

Abstract: Tumor tissue oxygenation significantly affects the outcome of radiotherapy. Real-time monitoring of tumor hypoxia is highly desirable for effective radiotherapy, and is the basis for improved treatment because hypoxic tumor cells are more resistant to radiation damage than fully oxygenated cells. We propose to use Cerenkov imaging to monitor tumor hypoxia by means of tissue blood oxygenation without the need for any exogenous contrast agent. Using a rodent hypoxia model, we demonstrate that Cerenkov imaging can be used as a noninvasive and noncontact method to measure tissue blood oxygenation level during radiation delivery. The data from Cerenkov imaging were validated using near infrared spectrometry methods. The results demonstrate the feasibility of using Cerenkov imaging to monitor tumor hypoxia during therapeutic radiation delivery.

Source: Optics Letters

DOI: 10.1364/ol.42.003101

Authors: Xiaofeng Zhang, Sai Kit Lam, Gregory Palmer, Shiva Das, Mark Oldham, Mark Dewhirst

Institutions: Duke Medical Center, University of North Carolina at Chapel Hill

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Duke University, School of Medicine, Duke University