Work

Decreased placental mitochondrial DNA-content in response to air pollution during in utero life

Year: 2011

Type: dissertation

Abstract: Ambient particulate matter is of great concern to human health. In this cross-sectional study, we investigated the influence of PM10 exposure during pregnancy on the mtDNA-content, an established marker of mitochondrial damage and dysfunction. We hypothesized that mtDNA-content changed during pregnancy in response to PM10 exposure and may underlie susceptibility to mitochondrial dysfunction. Our findings indicate a potential window for susceptibility by trimester exposure that may adversely affect mitochondrial function and possibly foetal outcome. Placental mtDNA-content is associated with distance to major road, a surrogate for traffic-related air pollution.

Source: Document Server@UHasselt (UHasselt)

Authors: Janssen, Bram, Pieters, Nicky, Munters, Elke, Smeets, Karen, Cuypers, Ann, Penders, Joris, Vangronsveld, Jaco, Gyselaers, Wilfried, Nawrot, Tim

Language: English

Topic: Air Quality and Health Impacts

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2744058028

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