Year: 2017
Type: preprint
Abstract: We propose a mathematical model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we solve analytically using separation of variables. In addition to the conventional interlayer continuous mass transfer boundary conditions, we consider also the case of finite mass transfer resistance, which corresponds to the case of a coated capsule. The drug concentration in the core and through all layers, as well as in the external release medium, is then given in terms of a Fourier series that we compute numerically to characterize the drug release mechanism.
Source: arXiv (Cornell University)
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2744516297