PBX1 attributes as a determinant of connexin 32 downregulation inHelicobacter pylori-related gastric carcinogenesis
Year: 2017
Type: article
Abstract: AIM: )-associated gastric carcinogenesis. METHODS: . RESULTS: infection. Enforced overexpression or RNAi-mediated knockdown of PBX1 contributed to the diminished or restored Cx32 expression in GES-1 and the gastric carcinoma cell line BGC823, respectively. Finally, dual-luciferase reporter assay in HEK293T cells showed that Cx32 promoter activity decreased by 30% after PBX1 vector co-transfection, indicating PBX1 as a transcriptional downregulator of Cx32 by directly binding to its promoters. CONCLUSION: -associated gastric carcinogenesis.
Institutions: Central South University, Third Xiangya Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2744652301