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Complete regression of cutaneous metastases with systemic immune response in a patient with triple negative breast cancer receiving p53MVA vaccine with pembrolizumab

Year: 2017
Type: article
Study design: Case Report
Abstract: A heavily pretreated patient with triple negative breast cancer distinguished by cutaneous metastases received p53MVA vaccine in combination with pembrolizumab. Her cutaneous metastases regressed and after 2 cycles of therapy, a skin biopsy showed a complete pathological response. Systemic response was confirmed with restaging CT and bone scans. Activation of p53-specific T cell responses and elevation of multiple immune response genes in peripheral blood correlated with the rapid clinical response which lasted for 6 months after the initiation of combined therapy.
DOI: 10.1080/2162402x.2017.1363138
Authors: Yuan Yuan, Ferdynand J. Kos, Ting-Fang He, Hongwei H. Yin, Mengsha Li, Nicola Hardwick, Kathryn Zurcher, Daniel Schmolze, Peter Lee, Raju K. Pillai, Vincent Chung, Don J. Diamond
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,913
Awards: G432865532, G5487787631, G6569458179, G772794905, CLINICAL EVALUATION OF A POXVIRUS VACCINE TARGETING P53, G8780689059, G9000092632, G9000145270
OpenAlex ID: W2744960134
FWCI: 0.969
Cites: 20
Cited by: 23
Related to: 10