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Role of nerve–muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing

Year: 2017
Type: article
Abstract: Skeletal muscle ageing is characterised by atrophy, a deficit in specific force generation, increased susceptibility to injury, and incomplete recovery after severe damage. The hypothesis that increased generation of reactive oxygen species (ROS) in vivo plays a key role in the ageing process has been extensively studied, but remains controversial. Skeletal muscle generates ROS at rest and during exercise. ROS can cause oxidative damage particularly to proteins. Indeed, products of oxidative damage accumulate in skeletal muscle during ageing and the ability of muscle cells to respond to increased ROS becomes defective. The aim of this review is to examine the evidence that ROS manipulation in peripheral nerves and/or muscle modifies mechanisms of proteostasis in skeletal muscle and plays a key role in initiating sarcopenia.
DOI: 10.1113/jp274336
Authors: Aphrodite Vasilaki, Arlan Richardson, Holly Van Remmen, Susan V. Brooks, Lisa Larkin, Anne McArdle, Malcolm J. Jackson
Institutions: University of Liverpool, Arthritis Research UK, Oklahoma City VA Medical Center, OU Health, University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, University of Michigan
Language: English
Open Access status: hybrid
Estimated APC paid: $2,315
Funders: U.S. Department of Veterans Affairs, University of Michigan, National Institutes of Health, Medical Research Council, Biotechnology and Biological Sciences Research Council, National Institute on Aging
Awards: G2607168779, G2988294562, Molecular Mechanisms of Neuromuscular Interactions Underlying Age-Related Atrophy, G4033523274, G7477972846, A failure of neuroprotective redox signalling from skeletal muscle to motor neurons leads to loss of motor units with ageing, G9000106860, G947279425
OpenAlex ID: W2745084255
FWCI: 2.62
Cites: 55
Cited by: 44
Related to: 10