Work

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia

Year: 2017

Type: article

Abstract: Key Points RUNX1 maintains Myb and Myc enhancer activity and is required for leukemogenesis in vivo. RUNX1 inhibition impairs the growth of primary T-ALL patient cells without an effect on normal human hematopoietic cells.

Source: Blood

DOI: 10.1182/blood-2017-03-775536

Authors: AHyun Choi, Anuradha Illendula, John A. Pulikkan, Justine E. Roderick, Jessica Tesell, Jun Yu, Nicole Hermance, Lihua Julie Zhu, Lucio H. Castilla, John H. Bushweller, Michelle A. Kelliher

Institutions: University of Massachusetts Chan Medical School, University of Virginia

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Award: Mechanism(s) of TAL1- and NOTCH1-mediated Leukemogenesis

OpenAlex ID: W2745155203

FWCI: 7.635

Cites: 49

Cited by: 85

Related to: 10