Work

Colchicine: an ancient drug with novel applications

Year: 2017

Type: review

Abstract: Colchicine is a treatment for gout that has been used for more than a millennium. It is the treatment of choice for familial Mediterranean fever and its associated complication, amyloidosis. The 2009 U.S. Food and Drug Administration approval of colchicine as a new drug had research consequences. Recent investigations with large cohorts of patients with gout who have been taking colchicine for years have demonstrated novel applications within oncology, immunology, cardiology and dermatology. Some emerging dermatological uses include the treatment of epidermolysis bullosa acquisita, leucocytoclastic vasculitis, aphthous stomatitis and others. In this work we relate the history and the new horizon of this ancient medicine.

Source: British Journal of Dermatology

DOI: 10.1111/bjd.15896

Authors: B. Dasgeb, D. Kornreich, K. McGuinn, L. Okon, I. Brownell, D.L. Sackett