Work

Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia

Year: 2017

Type: article

Abstract: Retrospective studies suggest that there is high mortality in children with sickle cell anemia (SCA) and severe malaria. We assessed mortality in Ugandan children with severe malarial anemia (SMA, n = 232) or cerebral malaria (CM, n = 267) by sickle cell hemoglobin genotype. Admission and 2-year follow-up mortality did not differ among children with SMA who had homozygous form of sickle cell hemoglobin (HbSS) versus normal form of adult hemoglobin (admission, 0/22, 0%, vs. 1/208, 0.5%; follow-up, 1/22, 4.5%; 7/207, 3.4%, respectively; all P > 0.6). The single child with CM and HbSS survived. The study findings highlight the need for large prospective studies of malaria-related mortality in children with SCA.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.26745

Authors: Robert O. Opoka, Paul Bangirana, Richard Idro, Estela Shabani, Ruth Namazzi, Chandy C. John

Institutions: Makerere University, University of Minnesota, Indiana University School of Medicine

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Fogarty International Center, National Institute of Neurological Disorders and Stroke