Closing the Gap: Mouse Models to Study Adhesion in Secondary Palatogenesis
Year: 2017
Type: review
Abstract: Secondary palatogenesis occurs when the bilateral palatal shelves (PS), arising from maxillary prominences, fuse at the midline, forming the hard and soft palate. This embryonic phenomenon involves a complex array of morphogenetic events that require coordinated proliferation, apoptosis, migration, and adhesion in the PS epithelia and underlying mesenchyme. When the delicate process of craniofacial morphogenesis is disrupted, the result is orofacial clefting, including cleft lip and cleft palate (CL/P). Through human genetic and animal studies, there are now hundreds of known genetic alternations associated with orofacial clefts; so, it is not surprising that CL/P is among the most common of all birth defects. In recent years, in vitro cell-based assays, ex vivo palate cultures, and genetically engineered animal models have advanced our understanding of the developmental and cell biological pathways that contribute to palate closure. This is particularly true for the areas of PS patterning and growth as well as medial epithelial seam dissolution during palatal fusion. Here, we focus on epithelial cell-cell adhesion, a critical but understudied process in secondary palatogenesis, and provide a review of the available tools and mouse models to better understand this phenomenon.
Source: Journal of Dental Research
Authors: K.J. Lough, K.M. Byrd, D.C. Spitzer, S.E Williams
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: Sidney Kimmel Foundation for Cancer Research, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Dental and Craniofacial Research, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina at Chapel Hill
Awards: G1824186229, G1948135505, G2323592246, Mechanisms of Oral Epithelial Differentiation, Cell-cell adhesion in regulation of mammalian palatogenesis, G4916871411, FaceBase 2 Coordinating Center, Idenfication of miRNAs involved midfacial development and clefting, Center for Gastrointestinal Biology and Disease
OpenAlex ID: W2746234292