Work

The role of Toll-Like Receptor 2, 4 and 9 in atherosclerosis

Year: 2016

Type: dissertation

Abstract: Inflammation, especially Toll-Like Receptors (TLRs), are playing an important role in atherosclerosis. Double knockout of Apolipoprotein E (ApoE) and TLR 9 leaded to an exacerbation of lesion severity with an increased plaque size, lipid content, accumulation of macrophages and dendritic cells, while the collagen content was reduced. The depletion of CD4+ cells in ApoE-/-:TLR9-/- mice, resulted in a significant reduction of plaque. Furthermore, treatment of ApoE-/- mice with a TLR 9 agonist led to a reduction in lesion severity.

Source: mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Author: Christian Hausding

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2746469255

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