Work

Neuronal Ablation of IKK2 Decreases Lesion Size and Improves Functional Outcome after Spinal Cord Injury in Mice.

Year: 2017

Type: article

Abstract: mice exhibited reduced lesion volume but comparable microglial/leukocyte responses after SCI. In parallel, interleukin (IL)-1β expression was significantly decreased within the lesioned spinal cord, whereas IL-5, IL-6, IL-10, tumor necrosis factor (TNF) and chemokine (C-X-C motif) ligand 1 were unchanged compared to control mice. We conclude that conditional ablation of IKK2 in neurons, resulting in reduced neuronal NF-B signaling, and lead to protective effects after SCI and propose the neuronal classical NF-κB pathway as a potential target for the development of new therapeutic, neuroprotective strategies for SCI.

Source: PubMed

Authors: Ditte Gry Ellman, Hans Gram Novrup, Louise Helskov Jørgensen, Minna Christiansen Lund, Minna Yli-Karjanmaa, Pernille Marie Madsen, Jonas Heinrich Vienhues, Safinaz Dursun, John R Bethea, Karin Lykke-Hartmann, Roberta Brambilla, Kate Lykke Lambertsen

Institutions: University of Southern Denmark, Odense University Hospital, University of Miami, Drexel University, Aarhus University

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: Molecular mechanisms of the protective function of oligodendroglial TNFR2: a new therapeutic target in neuro-immune disease, Does microglial TNFR2 contribute to the protective role of membrane TNF in EAE?

OpenAlex ID: W2746485863

FWCI:

Cites: 57

Cited by: 2

Related to: 10