Proactive Inhibitory Control and Subjective Trial Outcome Certainty Influence Response Inhibition Processes: An fMRI study
Year: 2017
Type: dissertation
Abstract: Previous research has demonstrated that prior information about the likelihood of a stop-signal is associated with similar cortical activation patterns as is evident during response inhibition itself.Therefore, it has been proposed that proactive inhibitory control, as elicited by such prior information, may influence the implementation of reactive response inhibition processes in the cortex.To investigate this, a cued stop-signal task (cues: 0%, 25% and 66%) was implemented in combination with fMRI data acquisition, using a within-subjects design.Dependent variables included relevant behavioural measures and fMRI BOLD signals such as activity from predefined regions of interest (ROIs).Data from 31 participants were included in the study.Behavioural results revealed an increase in go-trial reaction time with increasing stop-signal probability, while the effect on stop-signal reaction times did not reach significance.Imaging results revealed that while go-trial activity depended on both ROI and stop-signal probability, no such effect was found for stop-trial activity.However, stop-trial activity was overall higher in the 66% condition than in the 25% condition and demonstrated a right-lateralised trend.The decrease in go-and stop-trial activity in the 25% condition compared to the other stop-signal probability conditions further indicate that while proactive inhibitory control is increased with increasing stop-signal probability, subjective trial outcome certainty may not be influenced in the same linear way.It is suggested that both of these processes influence response inhibition processes, evident in both go-and stop-trial activity.V
Author: Mari S. Messel
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2747127574