Year: 2017
Type: dissertation
Abstract: Group B Streptococcus (GBS), also known as Streptococcus agalactiae, are bacteria that commonly reside in the vagina of healthy women.GBS is not a major cause of infection in normal adults.However, newborns can acquire GBS from colonized mothers during birth leading to neonatal infections.Alternatively, GBS can migrate from the vagina to the uterus, during pregnancy leading to in utero infection and significant adverse pregnancy outcomes such as preterm birth and stillbirth.To successfully establish an in utero infection, GBS must bypass the host immune response to traffic from the vagina into the pregnant uterus in a process known as ascending infection.Despite the significant impact on perinatal and neonatal health, the mechanisms of GBS vaginal colonization and ascending infection are not completely understood.An increased understanding of these processes will enable the development of novel therapeutic
Author: Jay Vornhagen
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2747190288