A4 The transmission dynamics over ten years of human immunodeficiency virus type 1 in Vietnam
Year: 2017
Type: article
Study design: Observational Study
Abstract: The HIV epidemic in Vietnam is evolving from a concentrated epidemic in men who inject drugs and female sex workers to sub-epidemics of men who have sex with men and to the general population. Understanding the infection dynamics and the temporal and geographical trends in transmission events in the population are crucial for national HIV control and prevention strategies. In collaboration with two largest primary and referral hospitals for HIV treatment in Ho Chi Minh City and Ha Noi, we have conducted cohort studies of over 1,000 patients on anti-retroviral therapy (ART) and have access to approximately 800 HIV polymerase sequences from ART-naïve patients collected over a 10-year period from 2004 to 2014. The first-line ART cohorts includes 220 patients initiating ART in Ho Chi Minh City from 2005 to 2007 and 650 patients initiating ART in Hanoi from 2011 to 2015. The median age was 36 years and 70% were male. Median CD4 cell count was 90 cells/mm3 and the median HIV RNA level was 5.2 log10 copies/mL. The second-line ART cohort enrolled 330 patients who failed first-line ART and were switched to second-line ART from 2006 to 2011. We propose to perform phylogenetic analyses including molecular clock calculations to investigate HIV evolution, HIV transmission dynamics, and trends over 10 years in Vietnam. HIV transmission dynamics includes the pattern of transmission, transmission of drug resistant strains, drug-resistance mutational pathways, and rapidity of viral spread.
Source: Virus Evolution
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,304
OpenAlex ID: W2747456290