“UPRegulation” of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses
Year: 2017
Type: article
Abstract: We recently demonstrated that targeting the unfolded protein response (UPR) protein GRP78 down-regulates CD47 expression, resulting in increased tumor macrophage infiltration and inhibited resistance to anti-estrogen therapy. We now show new data indicating that anti-estrogen therapy regulates CD47 expression and implicates its ligand, thrombospondin-1, in regulation of tumor macrophage infiltration. Moreover, GRP78 and CD47 co-expression is associated with poor prognosis in breast cancer patients, suggesting the existence of crosstalk between UPR and immunity that regulates therapeutic responses in breast cancer.
Source: Biomarker Research
Authors: Katherine L. Cook, David R. Soto-Pantoja
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,890
Funders: Prevent Cancer Foundation, Comprehensive Cancer Center at Wake Forest Baptist Medical Center, National Institutes of Health, National Cancer Institute, National Center for Advancing Translational Sciences, Wake Forest Clinical and Translational Science Institute, Wake Forest School of Medicine
Awards: G171052541, Wake Forest Clinical and Translational Science Award, G2577419345, Therapeutic targeting of CD47 regulates tumor cell bioenergetics and mitophagy, G3394859627, G3786307129, G4491225660, G5197303093, Institutional Career Development Core, G7220847018, G8701503245, G9000145266, G9000281046, Cancer Center Support Grant
OpenAlex ID: W2748181983