Year: 2017
Type: review
Abstract: Bioprinting is a quickly progressing technology, which holds the potential to generate replacement tissues and organs. Stem cells offer several advantages over differentiated cells for use as starting materials, including the potential for autologous tissue and differentiation into multiple cell lines. The three most commonly used stem cells are embryonic, induced pluripotent, and adult stem cells. Cells are combined with various natural and synthetic materials to form bioinks, which are used to fabricate scaffold-based or scaffold-free constructs. Computer aided design technology is combined with various bioprinting modalities including droplet-, extrusion-, or laser-based bioprinting to create tissue constructs. Each bioink and modality has its own advantages and disadvantages. Various materials and techniques are combined to maximize the benefits. Researchers have been successful in bioprinting cartilage, bone, cardiac, nervous, liver, and vascular tissues. However, a major limitation to clinical translation is building large-scale vascularized constructs. Many challenges must be overcome before this technology is used routinely in a clinical setting. Stem Cells Translational Medicine 2017;6:1940-1948.
DOI: 10.1002/sctm.17-0148
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,963
Funders: National Science Foundation, Diabetes Action Research and Education Foundation, University of Pennsylvania, Pennsylvania State University, Osteology Foundation, National Institutes of Health, National Institute of Child Health and Human Development, Division of Civil, Mechanical and Manufacturing Innovation, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G2598047015, CAREER: Hybrid Bioprinting of Engineered Vascularized Endocrine Tissues, G3068013908, G3364748509, G3853450119, Career Development Program in Women's Health Research at Penn State, Bioprinting of Bone Tissue into Defect Sites on Animal Models in Surgery Settings, G8662042959, G970689269
OpenAlex ID: W2748286045