Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility
Year: 2017
Type: article
Study design: Observational Study
Abstract: We conducted an exome-wide association study of childhood acute lymphoblastic leukemia (ALL) among Hispanics to confirm and identify novel variants associated with disease risk in this population. We used a case-parent trio study design; unlike more commonly used case-control studies, this study design is ideal for avoiding issues with population stratification bias among this at-risk ethnic group. Using 710 individuals from 323 Guatemalan and US Hispanic families, two inherited SNPs in ARID5B reached genome-wide level significance: rs10821936, RR = 2.31, 95% CI = 1.70-3.14, p = 1.7×10-8 and rs7089424, RR = 2.22, 95% CI = 1.64-3.01, p = 5.2×10-8. Similar results were observed when restricting our analyses to those with the B-ALL subtype: ARID5B rs10821936 RR = 2.22, 95% CI = 1.63-3.02, p = 9.63×10-8 and ARID5B rs7089424 RR = 2.13, 95% CI = 1.57-2.88, p = 2.81×10-7. Notably, effect sizes observed for rs7089424 and rs10821936 in our study were >20% higher than those reported among non-Hispanic white populations in previous genetic association studies. Our results confirmed the role of ARID5B in childhood ALL susceptibility among Hispanics; however, our assessment did not reveal any strong novel inherited genetic risks for acute lymphoblastic leukemia among this ethnic group.
Source: PLoS ONE
Authors: Natalie P. Archer, Virginia Perez-Andreu, Ulrik Stoltze, Michael E. Scheurer, Anna V. Wilkinson, Ting-Nien Lin, Maoxiang Qian, Charnise Goodings, Michael D. Swartz, Nalini Ranjit, Karen R. Rabin, Erin C. Peckham-Gregory, Sharon E. Plon, Pedro A. de Alarcon, Ryan C. Zabriskie, Federico Antillon-Klussmann, Cesar R. Najera, Jun J. Yang, Philip J. Lupo
Institutions: The University of Texas at Austin, St. Jude Children's Research Hospital, Copenhagen University Hospital, Baylor College of Medicine, Michael & Susan Dell Center for Healthy Living, The University of Texas Health Science Center at Houston, Peoria campus of the University of Illinois System, Universidad Francisco Marroquín
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: Whole Genome Approaches to Define the Inherited Basis of Childhood Cancer, ARID5B and disparities of childhood leukemia, Training Program in Pediatric Cancer Epidemiology and Control, G418187648, The Intersection Between Childhood Cancer and Congenital Anomalies: Identifying Novel Cancer Predisposition Syndromes, Baylor College of Medicine Cancer Center - Cancer Center Support Grant
OpenAlex ID: W2748286944