Work

Covalent modification of biological targets with natural products through Paal–Knorr pyrrole formation

Year: 2017

Type: review

Abstract: Covering: up to June 2017Natural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems.

Source: Natural Product Reports

DOI: 10.1039/c7np00024c

Authors: Alexander Kornienko, James J. La Clair

Institutions: Texas State University, University of California San Diego, Xenobe Research Institute

Language: English

Topic: Synthesis and Characterization of Pyrroles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: G4744606257, Mode of Action of the Amaryllidaceae Alkaloid Lycorine-Promising Anticancer Agent