Work

Influence of adipogenesis and high fat diet on the development of cell stress markers in adipose tissue

Year: 2013

Type: dissertation

Abstract: We could show that markers for the erURP and mtUPR alter during the course of differentiation. Furthermore, the cells activate an ER-associated degradation (ERAD). In vivo, we observed a compensatory adaptive response to counteract the critical requirement of Grp78 or Cpn60 via up-regulation of ERAD in the Grp78+/- mice and the Cpn60+/- mice. In conclusion, stress responses are somehow involved in the development of obesity.

Source: mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Author: Stephanie May

Language: English

Topic: Endoplasmic Reticulum Stress and Disease

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2748682142

Cites: 109

Cited by:

Related to: 10