Work

Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling

Year: 2017

Type: article

Abstract: . Specifically targeting VEGFR2 in the tumor vasculature, the chemically synthesized chimeric UIM peptide, UPI, causes non-functional tumor angiogenesis, retards tumor growth, and increases survival rates in several tumor models. The authors showed that UPI binds ubiquitylated VEGFR2 to form a supercomplex in an Ub-dependent fashion. Collectively, the UPI targeting strategy offers a potentially novel treatment for cancer patients who are resistant to current anti-angiogenic therapies. In this review, the authors outline the main points of this research specifically as a potential application for glioma tumor therapy.

Source: Vessel Plus

DOI: 10.20517/2574-1209.2016.01

Authors: Yunzhou Dong, Hao Wu, Jerry Dong, Kai Song, Habibunnabi Ashiqur Rahman, Rheal Towner, Hong Chen

Institutions: Boston Children's Hospital, Harvard University, Oklahoma Medical Research Foundation

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: American Heart Association, Oklahoma Center for the Advancement of Science and Technology, Oklahoma Medical Research Foundation, Institut National de la Santé et de la Recherche Médicale, National Institutes of Health, National Heart, Lung, and Blood Institute, National Center for Research Resources

Awards: G1278793335, G1790241457, Molecular mechanisms of epsins in obesity, G2681320608, Mechanisms regulating VEGF receptors in diabetic angiogenesis, "The Role of Signaling Adaptor Protein Epsin in Atherosclerosis", Epsin in Angiogenesis and Vascular Remodeling, G7761446785, G95573990

OpenAlex ID: W2748957979

FWCI: 0.679

Cites: 40

Cited by: 8

Related to: 10